MORFORA - 汇融科技

MORFORA® bioactive skin care is launched with decades of solid clinical study on stem cells, together with genetic platform developed by HEROSTEM® in 2018.

The product aims to help anti-aging by optimizing skin cells activity and migration with its innovative extracellular matrix reconstitution technology - 『MORFTECH®』.

墨芙拉 MORFORA

Simulated extracellular matrix technology

MORFORA® bioactive skin care is launched with decades of solid clinical study on stem cells, together with genetic platform developed by HEROSTEM® in 2018.

The product aims to help anti-aging by optimizing skin cells activity and migration with its innovative extracellular matrix reconstitution technology - 『MORFTECH®』.

HEROSTEM® innovated MORFTECH® technology - simulated ECM (extracellular matrix) proteins of early fetal skin tissue, based on our stem cell and genetic engineering facilities. By improving and stimulating extracellular environment, we are able to faciliate cell activities, promote cell migration and proliferation, which makes anti-aging viable.

of anti-aging

A new definition

The extracellular matrix (ECM) is a three-dimensional network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.

Human extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various cells. Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest.

Structural

Proteins

Proteoglycans and

Non-proteoglycan

polysaccharide

Cell adhesion

proteins

Structural proteins

Polysaccharide

Cell Adhesion Proteins

Collagens are the most abundant protein in the ECM, providing structural support, Collagen is exocytosed in precursor form (procollagen), which is then cleaved by procollagen proteases to allow extracellular assembly; elastin proteins provide elasticity to resident cells, allowing them to stretch when needed and then return to their original state.

Fibronectin connects cells with collagen fibers in the ECM, allowing cells to move through the ECM. Fibronectins bind collagen and cell-surface integrins, causing a reorganization of the cell's cytoskeleton to facilitate cell movement. Laminins form networks of web-like structures that resist tensile forces in the basal lamina. They also assist in cell adhesion. Laminins bind other ECM components such as collagens and nidogens.

Structural Protein

Cell adhesion proteins

Glycosaminoglycans (GAGs) are carbohydrate polymers and mostly attached to extracellular matrix proteins to form proteoglycans (hyaluronic acid is a notable exception; see below). Proteoglycans have a net negative charge that attracts positively charged sodium ions (Na+), which attracts water molecules via osmosis, keeping the ECM and resident cells hydrated. Proteoglycans may also help to trap and store growth factors within the ECM. Hyaluronic acid in the extracellular space confers upon tissues the ability to resist compression by providing a counteracting turgor force by absorbing significant amounts of water.

NMPA class II medical device

Bioactive dermal booster

·Take one solution with meso-therapy every 3 months;

·Use hydrating mask before and after.

·Clean face before the treatment;

·Do not use twice after opening the vial；

·Do not use if solution appears unclear and non-transparent；

·Store at -20℃, defrost at 4℃;

·Avoid laser-like treatment on the same day.

Specification
Q&A

Composition

Recombinant type III collagen

Cat. No.

GB02.01

Type M；5mL

Specs

Source

E. coli.

Molecule Weight

Approximately 60 kDa

Applications

For coverage and nursing for non-chronic wounds, providing microenvironment for chronic healing.

Appearance

Colorless

Storage

-20℃ over one year

Purity

> 95 % by SDS-PAGE analyses. > 95 % by HPLC analyses.

Endotoxines

< 0.01 EU/mg

Usage

This GMP product can be for research use or further manufacturing use.

How to store the solution

Because of the instability of protein, the product should be stored at -20℃ over a year; Store at -80℃ for longer term. Do not store over 14 days at 2-8℃.

Caution of usage?

Make sure of no protein allergy history. Stop using if the solution shows abnormal appearance, and contact your vendor immediately. Defrost at 4℃, and use the product after it turns completely into liquid.

Specification

COMPOSITION	rH BIOACTIVE PROTEIN
CAT.NO	GB02.01
SPECS	Type M, 5mL
PURITY	> 95 % BY SDS-PAGE ANALYSES. > 95 % BY HPLC ANALYSES.
MOLECULE WEIGHT	APPROX. 60kD
APPLICATIONS	COVERAGE AND NURSING FOR NON-CHRONIC WOUNDS, PROVIDING MICROENVIRONMENT FOR CHRONIC HEALING.
ENDOTOXINES	< 0.01EU/MG
APPEARENCES	COLORLESS
USAGE	FOR RESEARCH OR FURTHER MANUFACTURE USE
STORAGE	-20℃

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